Inter vs Sassuolo prediction, H2H and probable lineups, September 21, 2025

By Author On Sep 21, 2025

As Inter Milan prepares to face Sassuolo on September 21, 2025, this analysis offers a comprehensive prediction to guide fans and bettors alike. We cover head-to-head statistics, possible starting lineups, and key betting tips to help you understand this Serie A clash.

Match Overview

Inter, historically a Serie A powerhouse, enters this game with a strong home record and a well-balanced squad. Sassuolo, known for their dynamic attack and disciplined midfield, will look to challenge Inter’s dominance and secure crucial points on the road.

Head-to-Head (H2H) Analysis

In their last 10 meetings, Inter has won 7 matches, showcasing clear superiority.
Sassuolo has managed to secure 2 wins, indicating occasional threats.
One draw in recent encounters reflects the competitive nature of this fixture.
Inter’s home advantage has been significant, with multiple high-scoring wins at San Siro.

These stats suggest Inter holds a tactical edge, but Sassuolo’s ability to capitalize on counterattacks means the match could produce an exciting contest.

Probable Lineups

Inter Milan (Expected Formation: 3-5-2):

Goalkeeper: Handanović
Defenders: Skriniar, de Vrij, Bastoni
Midfielders: Barella, Brozović, Calhanoglu, Dumfries, Dimarco
Forwards: Lautaro Martínez, Džeko

Betting Tips & Predictions

Match Result: Inter is favored to win given their home form and consistency.
Both Teams to Score: Likely, as Sassuolo’s attacking style often breaks down opponents’ defenses.
Over/Under Goals: Expect over 2.5 goals, considering Inter’s attacking prowess and Sassuolo’s forward momentum.
Key Player to Watch: Lautaro Martínez, expected to influence the game decisively for Inter.

Final Score Prediction

Inter Milan 3 – 1 Sassuolo

This scoreline accounts for Inter’s home advantage and offensive power, balanced against Sassuolo’s ability to find the net.