Napoli vs Pisa prediction, H2H and probable lineups, 22.09.2025

By Author On Sep 22, 2025

As Napoli prepare to face Pisa on September 22, 2025, both teams enter this clash seeking momentum in their respective campaigns. This article provides a comprehensive Napoli vs Pisa prediction, analyzing their head-to-head (H2H) record, current form, lineup news, and key betting insights.

Napoli vs Pisa: Recent Form and Match Context

Napoli, a top contender in Serie A, have consistently shown strong performances at home. Their dynamic attacking style, led by key players, puts them in a favorable position against Pisa, who currently compete in Serie B but have proven resilient on their travels.

Napoli’s recent form: Unbeaten in their last five Serie A matches, showcasing solid defense and lethal counterattacks.
Pisa’s recent form: Mixed results with a couple of draws and wins, but their away form reveals some vulnerabilities.

This match presents a classic scenario where high-tier quality meets determined underdog spirit, shaping an intriguing contest.

Head-to-Head (H2H) Record

The historical encounters between Napoli and Pisa are limited due to their different league status, but previous cup meetings have favored Napoli:

Napoli have won 3 of the last 4 meetings.
Pisa’s only victory came in a tightly contested Italian Cup tie.
Goal difference heavily favors Napoli, with a +5 margin in these matches.

This H2H overview indicates Napoli’s dominance, especially in home fixtures.

Expected Lineups and Key Players

Napoli probable lineup:

Goalkeeper: Alex Meret
Defense: Di Lorenzo, Kim Min-jae, Rrahmani, Mario Rui
Midfield: Anguissa, Lobotka, Zieliński
Attack: Kvaratskhelia, Osimhen, Politano

Injury updates confirm all key Napoli players are fit and expected to start, maintaining their preferred tactical setup.

Napoli vs Pisa Prediction and Betting Tips

Considering Napoli’s home advantage, consistent form, and superior squad depth, Napoli is strongly favored to secure a win in this match. Pisa’s resilience may limit the goal margin, but an upset appears unlikely.

Key Prediction Points:

Expected scoreline: Napoli 3 – 1 Pisa
Napoli to Keep a Clean Sheet: Unlikely due to Pisa’s attacking threats
Over/Under Goals: Expect over 2.5 goals given Napoli’s offensive firepower

Betting Tips:

Back Napoli to win with a handicap (-1).
Consider the “Both Teams to Score” market as viable.
Look for value odds on Napoli’s leading scorer to find the net.

Conclusion

The Napoli vs Pisa showdown on September 22 promises an engaging contest with a clear edge for Napoli, bolstered by their H2H record, lineup strength, and superior recent form. This prediction favors a confident home victory supported by incisive attacking play and organized defense.