Newcastle vs Benfica prediction, H2H and probable lineups, October 21, 2025

By Author On Oct 21, 2025

It’s another big European night as Newcastle United take on Benfica in the Champions League on October 21, 2025. The Magpies are looking to bounce back after a shaky start in their group, while Benfica will be hoping to keep their good run going. St. James’ Park should be rocking for this one—expect noise, energy, and possibly a few surprises.

Form Guide

Newcastle have had a mixed few weeks. A strong win over Brentford in the league was followed by a tough draw against PSG in Europe. Eddie Howe’s side look dangerous in attack but still seem to struggle when defending counterattacks.

Benfica, on the other hand, are flying in Portugal. They’ve won four of their last five matches and haven’t lost since early September. Roger Schmidt’s men have been consistent both home and away, showing great balance between experience and young energy.

Head-to-Head

These two sides haven’t met often, but their few meetings have produced fireworks. The last time they clashed, Benfica edged Newcastle over two legs in the Europa League back in 2013. This time, both squads are completely different, but the intensity will be the same.

St. James’ Park is known to intimidate visiting teams, yet Benfica’s European pedigree means they won’t be fazed easily.

Team News

For Newcastle, Alexander Isak is expected to return to the starting lineup after recovering from a minor knock. Callum Wilson and Anthony Gordon are both fit, but Harvey Barnes remains sidelined.

Benfica are still without their captain Nicolás Otamendi due to suspension, which could open up a spot for young António Silva. Ángel Di María might be rested, though Schmidt could still start him to add that extra bit of flair and experience.

Prediction

Players to Watch

Alexander Isak (Newcastle): The Swedish striker has been in sharp form lately. His movement and finishing could cause real problems for Benfica’s defense.

João Mário (Benfica): A key creative outlet who can turn a game around with his passing and awareness. His experience in big European nights makes him one to watch.

Betting Tips

Both Teams to Score: Yes – both sides love to attack and have leaky defenses at times.
Over 2.5 Goals: Likely – with the attacking quality on display, goals are almost guaranteed.
Anytime Goalscorer: Alexander Isak – back from injury and hungry to make an impact.

Wrap-Up

Newcastle vs Benfica has all the makings of a cracking Champions League tie. Both clubs have plenty to play for, and with electric atmospheres expected, this could be one of the most entertaining games of the group stage. Whether you’re a fan or a bettor, this is one you won’t want to miss.