PSV vs Napoli prediction, H2H and probable lineups, October 21, 2025

By Author On Oct 21, 2025

Champions League nights are back, and we’ve got a tasty one coming up in Eindhoven as PSV host Napoli. Both sides love attacking football, so we could be in for a wild one here. PSV will be banking on their strong home record, while Napoli come in looking to bounce back after some shaky recent form.

Current Form

PSV are flying high domestically, smashing goals for fun and showing serious confidence. They’ve looked sharp in the Champions League too, especially at home where they rarely drop points.

Napoli, on the other hand, have been a bit inconsistent this season. One game they look unstoppable, the next they’re struggling to find rhythm. Still, they’ve got enough quality in attack to trouble anyone on their day.

Head-to-Head Record

These two haven’t faced off too often, but the last few meetings were tight affairs. PSV have managed to frustrate Napoli before, especially in Eindhoven, where the home crowd really makes a difference. Napoli’s European experience, though, might give them an edge this time.

Team News

PSV: Manager Peter Bosz will likely stick with his usual front three, led by Luuk de Jong. No major injury concerns, though a couple of players are carrying knocks and might start on the bench.

Napoli: Walter Mazzarri’s men are still without a few key names in defense. Victor Osimhen should start up front, but there are questions over who partners him in attack. Expect Politano or Kvaratskhelia to make the difference from the wings.

Predicted Lineups

PSV (4-3-3): Benítez – Teze, Boscagli, Obispo, Dest – Veerman, Tillman, Schouten – Bakayoko, De Jong, Lozano

Napoli (4-3-3): Meret – Di Lorenzo, Rrahmani, Juan Jesus, Olivera – Anguissa, Lobotka, Zielinski – Politano, Osimhen, Kvaratskhelia

Players to Watch

Luuk de Jong (PSV): The captain’s been in beast mode this season, scoring headers for fun. If Napoli’s defense slips even a little, he’ll punish them.

Victor Osimhen (Napoli): You just can’t ignore him. His pace, power, and hunger in front of goal can turn any game around in a flash.

Prediction

This one feels close. PSV’s home form is no joke, but Napoli can’t be counted out with their attacking firepower. Expect goals on both ends and maybe some drama late on.

Prediction: PSV 2–2 Napoli

Betting Tips

Both Teams to Score: Looks like a strong pick given both sides’ attacking style.
Over 2.5 Goals: Could easily happen with these two going all-out.
Anytime Scorer: Luuk de Jong or Osimhen are good shouts.

Final Thoughts

Expect fireworks in Eindhoven! PSV will want to prove themselves against a top European side, while Napoli need a statement result to keep their campaign alive. One thing’s for sure – this game won’t be boring.